Is pain experience as diverse as our populations? This week I came across an interesting meta-analysis.
A meta-analysis (MA) is one of the strongest types of evidence there is. Some place it at the top; others, 2nd after evidence-based clinical practice guidelines. (For more on strength of evidence, click here.)
MA is not merely a review of literature, but is a statistical integration of studies on the same topic. MA that is based on integration of randomized controlled trials
(RCTs) or experimental studies is the strongest type of MA. MA based on descriptive or non-experimental studies is a little less strong, because it just describes things as they seem to be; & it cannot show that one thing causes another.
MA example: This brand, new MA included 41 peer-reviewed, English-language, experimental studies with humans: Kim HJ, Yang GS, Greenspan JD, Downton KD, Griffith KA, Renn CL, Johantgen M, Dorsey SG. Racial and ethnic differences in experimental pain sensitivity: Systematic review and meta-analysis. Pain. 2016 Sep 24 [Epub ahead of print] doi: 10.1097/j.pain.0000000000000731. PMID: 27682208. All 41 studies used experimental pain stimuli such as heat, cold, ischemic, electrical and others and compared differences between racial/ethnic groups.
Main findings? “AAs [African Americans], Asians, and Hispanics had higher pain sensitivity compared to NHWs [non-Hispanic Whites], particularly lower pain tolerance, higher pain ratings, and greater temporal summation of pain.” (https://www.ncbi.nlm.nih.gov/pubmed/27682208) (Temporal summation is the increase in subjective pain ratings as a pain stimulus is repeated again and again.)
Critical thinking: Given that this is a well-done meta-analysis and that the pain was created by researchers in each study, how should this change
your practice? Or should it? How can you use the findings with your patients? Should each patient be treated as a completely unique individual? Or what are the pros & cons of using this MA to give us a starting point with groups of patients? [To dialogue about this, comment below.]
For more info? Request the full Kim et al. article via interlibrary loan from your med center or school
library using reference above. It is available electronically pre-publication. Also check out my blog on strength of different types of evidence.
Happy evidence hunting. -Dr.H
In pain management are you afraid to give comfort to your patients with appropriate medications? Are you afraid to be comforted when in pain? Have you encountered families or care partners, who are afraid to comfort their loved one in pain by giving pain medications?
information. We have to find evidence-based practices that can create a change of heart, if you will. As Zerwekh et al wrote: “Because fear is so influential in decisions to keep pain under control, palliative educational approaches must go beyond providing information to fill deficits in palliative knowledge.”

practice pain assessment & management safely. We know
that asking patients about suicidal intent does not cause them to commit suicide. Does asking patients about pain cause them to have it or to treat pain they don’t have? Hmmm…..
Myth #5: The Joint Commission pain standards caused a sharp rise in opioid prescriptions. This claim is completely contradicted by data from the
suggest that we might need new studies. I hope only that we won’t jump on the fear bandwagon. Keep practice EVIDENCE BASED, listen to patient/carepartner preferences & values, & use your judgment.